Abstract

Short Communication

Evaluation of long antigen exposition dendritic cell therapy (LANEX-DC®) in the adjuvant treatment of pancreatic cancer – results of a single center analysis

Frank Gansauge* and Bertram Poch

Published: 25 July, 2022 | Volume 6 - Issue 1 | Pages: 006-008

Introduction: Even after surgical resection and adjuvant chemotherapy in pancreatic cancer the 5-year disease-free survival times (DFS), as well as overall survival rates (OS), are still low and median survival times are below 2 years. Here we retrospectively analyzed the outcome of immunotherapy in the additional adjuvant treatment of pancreatic cancer with long antigen exposition dendritic cell therapy (LANEX-DC®) in 28 patients who were treated at our institution. 
Patients: Data were available from 28 patients. Dendritic cells (LAEX-DC®) were produced according to a recently published protocol.
Results: Therapy was well tolerated and no serious side effects were observed. The median disease-free survival times and the median survival times were 16,9 months and 29,4 months respectively. Five-year DFS and OS were 14,3% and 17,9%. 
Conclusion: We were able to show in a small cohort of patients that additional treatment with dendritic cells (LANEX-DC®) is highly effective and extends the median disease-free survival times as well as the median survival in the adjuvant treatment of pancreatic cancer, whereas the five-year overall survival still remains unsatisfactory.

Read Full Article HTML DOI: 10.29328/journal.acst.1001027 Cite this Article Read Full Article PDF

Keywords:

Pancreatic cancer; Dendritic cells; LANEX-DC®; Immunotherapy; Adjuvant

References

  1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019 Jan;69(1):7-34. doi: 10.3322/caac.21551. Epub 2019 Jan 8. PMID: 30620402.
  2. Groot VP, Rezaee N, Wu W, Cameron JL, Fishman EK, Hruban RH, Weiss MJ, Zheng L, Wolfgang CL, He J. Patterns, Timing, and Predictors of Recurrence Following Pancreatectomy for Pancreatic Ductal Adenocarcinoma. Ann Surg. 2018 May;267(5):936-945. doi: 10.1097/SLA.0000000000002234. PMID: 28338509.
  3. Oettle H, Neuhaus P, Hochhaus A, Hartmann JT, Gellert K, Ridwelski K, Niedergethmann M, Zülke C, Fahlke J, Arning MB, Sinn M, Hinke A, Riess H. Adjuvant chemotherapy with gemcitabine and long-term outcomes among patients with resected pancreatic cancer: the CONKO-001 randomized trial. JAMA. 2013 Oct 9;310(14):1473-81. doi: 10.1001/jama.2013.279201. PMID: 24104372.
  4. Conroy T, Hammel P, Hebbar M, Abdelghani MB, Wei AC. Canadian cancer trial group and the unicancer-GI-PRODIGE group. FOLFIRINOX or gemcitabine as adjuvant therapy for pancreatic cancer. N Eng J Med. 2018; 379: 2395-2406.
  5. Palucka K, Banchereau J. Cancer immunotherapy via dendritic cells. Nat Rev Cancer. 2012 Mar 22;12(4):265-77. doi: 10.1038/nrc3258. PMID: 22437871; PMCID: PMC3433802.
  6. Sadeghzadeh M, Bornehdeli S, Mohahammadrezakhani H, Abolghasemi M, Poursaei E, Asadi M, Zafari V, Aghebati-Maleki L, Shanehbandi D. Dendritic cell therapy in cancer treatment; the state-of-the-art. Life Sci. 2020 Aug 1;254:117580. doi: 10.1016/j.lfs.2020.117580. Epub 2020 Mar 20. PMID: 32205087.
  7. Lepisto AJ, Moser AJ, Zeh H, Lee K, Bartlett D, McKolanis JR, Geller BA, Schmotzer A, Potter DP, Whiteside T, Finn OJ, Ramanathan RK. A phase I/II study of a MUC1 peptide pulsed autologous dendritic cell vaccine as adjuvant therapy in patients with resected pancreatic and biliary tumors. Cancer Ther. 2008;6(B):955-964. PMID: 19129927; PMCID: PMC2614325.
  8. Nagai K, Adachi T, Harada H, Eguchi S, Sugiyama H, Miyazaki Y. Dendritic Cell-based Immunotherapy Pulsed With Wilms Tumor 1 Peptide and Mucin 1 as an Adjuvant Therapy for Pancreatic Ductal Adenocarcinoma After Curative Resection: A Phase I/IIa Clinical Trial. Anticancer Res. 2020 Oct;40(10):5765-5776. doi: 10.21873/anticanres.14593. PMID: 32988904.
  9. Gansauge F, Poch B, Kleef R, Schwarz M. Effectivity of long antigen exposition dendritic cell therapy (LANEXDC®) in the palliative treatment of pancreatic cancer. Curr Med Chem. 2013;20(38):4827-35. doi: 10.2174/09298673113206660290. PMID: 24083599.
  10. Gansauge F, Poch B. Effectivity of Long Antigen Exposition Dendritic Cell Therapy (LANEX-DC®) in the Adjuvant Treatment of Gastric Cancer. Clin Oncol. 2022; 7: 1929-31.
  11. Maeda S, Unno M, Yu J. Adjuvant and neoadjuvant therapy for pancreatic cancer. J Pancreatol. 2019; 2: 100-106.

Figures:

Figure 1

Figure 1

Figure 1

Figure 2

Similar Articles

Recently Viewed

  • Artificial Intelligence (AI) in the Chemical Field: Innovation and Risk Evaluation
    Luisetto M*, Edbey K, Mashori GR, Hamid GH, Gadama GP, Cabianca l and Latyshev OY Luisetto M*,Edbey K,Mashori GR,Hamid GH,Gadama GP,Cabianca l,Latyshev OY. Artificial Intelligence (AI) in the Chemical Field: Innovation and Risk Evaluation. Ann Adv Chem. 2025: doi: 10.29328/journal.aac.1001057; 9: 027-033
  • The Current Status of Renal Denervation in Hypertension Management
    Anil Avci*, Regaip Zehir and Mehmet Kaan Kirali Anil Avci*,Regaip Zehir,Mehmet Kaan Kirali. The Current Status of Renal Denervation in Hypertension Management. Ann Clin Hypertens. 2025: doi: 10.29328/journal.ach.1001039; 9: 015-017
  • Differentiation of the Non-dipping Blood Pressure Phenotype in Obstructive Sleep Apnea: An Observational Study
    Matilde Valencia-Flores*, Victoria Santiago-Ayala, Margarita Fernández López, Jorge Oseguera Moguel, Gerardo Payró Ramirez, Montserrat Reséndiz-Garcia, Montserrat Memetla-Argumedo, Gabriela Gaytán-Cervantes, Ramón Morales-Navarro, Carlos A. Aguilar-Salinas and Donald L. Bliwise Matilde Valencia-Flores*,Victoria Santiago-Ayala,Margarita Fernández López,Jorge Oseguera Moguel,Gerardo Payró Ramirez,Montserrat Reséndiz-Garcia,Montserrat Memetla-Argumedo,Gabriela Gaytán-Cervantes,Ramón Morales-Navarro,Carlos A. Aguilar-Salinas,Donald L. Bliwise. Differentiation of the Non-dipping Blood Pressure Phenotype in Obstructive Sleep Apnea: An Observational Study. Ann Clin Hypertens. 2025: doi: 10.29328/journal.ach.1001037; 9: 001-008
  • Evaluation of Long-term Antithrombotic Management for Atrial Fibrillation Patients with a History of Coronary Stent Implantation
    Kirsten Vyhmeister, Paul Gavaza, Murphy Nguyen, Grace Kang and Huyentran N Tran* Kirsten Vyhmeister, Paul Gavaza, Murphy Nguyen, Grace Kang, Huyentran N Tran*. Evaluation of Long-term Antithrombotic Management for Atrial Fibrillation Patients with a History of Coronary Stent Implantation. Ann Clin Hypertens. 2024: doi: 10.29328/journal.ach.1001035; 8: 001-006
  • Call to Action! Hypertension and Dyslipidemia in Mexico: Underestimated Deadly Duo
    Martin Rosas-Peralta, Héctor Galván-Oseguera, Luis Alcocer, Humberto Álvarez-López, Ernesto Cardona-Muñoz, Silvia Palomo-Piñón, Enrique Díaz-Díaz, Adolfo Chávez-Mendoza and José Manuel Enciso-Muñoz Martin Rosas-Peralta,Héctor Galván-Oseguera,Luis Alcocer,Humberto Álvarez-López,Ernesto Cardona-Muñoz,Silvia Palomo-Piñón,Enrique Díaz-Díaz,Adolfo Chávez-Mendoza,José Manuel Enciso-Muñoz. Call to Action! Hypertension and Dyslipidemia in Mexico: Underestimated Deadly Duo. Ann Clin Hypertens. 2024: doi: 10.29328/journal.ach.1001036; 8: 007-010

Read More

Most Viewed

Read More

Help ?