Abstract

Research Article

Endogenus toxicology: Modern physio-pathological aspects and relationship with new therapeutic strategies. An integrative discipline incorporating concepts from different research discipline like Biochemistry, Pharmacology and Toxicology

Luisetto M*, Naseer Almukhtar, Behzad Nili Ahmadabadi, Gamal Abdul Hamid, Ghulam Rasool Mashori, Kausar Rehman Khan, Farhan Ahmad Khan and Luca Cabianca

Published: 14 January, 2019 | Volume 3 - Issue 1 | Pages: 001-024

Many pathologic disease can be considered as related to an Endogenous toxicological moves and in time dependent way (kinetics and dynamic of the process). In this work starting from the analysis of relevant literature involved with different disease and related to the endogenous local micro- environment some global conclusion useful as new tools for innovative pharmacological strategies will be submitted to the researcher. Physiology, pathology concept linked to the endogenous toxicological local micro-environment status as new research instruments. The same carcinogenesis process can be related also to endogenous agents that may have a major contribution in spontaneously process. (Reactive oxygen species (ROS), which are involved in multiple cellular processes by physiologically transporting signal as a second messenger or pathologically oxidizing DNA, lipids, and proteins).

Read Full Article HTML DOI: 10.29328/journal.acst.1001004 Cite this Article Read Full Article PDF

Keywords:

Endogenous toxicology; Physiology; Pharmacological strategies; New pathogenetic theories; Cancer; Metastasys

References

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