Abstract

Research Article

Endogenus toxicology: Modern physio-pathological aspects and relationship with new therapeutic strategies. An integrative discipline incorporating concepts from different research discipline like Biochemistry, Pharmacology and Toxicology

Luisetto M*, Naseer Almukhtar, Behzad Nili Ahmadabadi, Gamal Abdul Hamid, Ghulam Rasool Mashori, Kausar Rehman Khan, Farhan Ahmad Khan and Luca Cabianca

Published: 14 January, 2019 | Volume 3 - Issue 1 | Pages: 001-024

Many pathologic disease can be considered as related to an Endogenous toxicological moves and in time dependent way (kinetics and dynamic of the process). In this work starting from the analysis of relevant literature involved with different disease and related to the endogenous local micro- environment some global conclusion useful as new tools for innovative pharmacological strategies will be submitted to the researcher. Physiology, pathology concept linked to the endogenous toxicological local micro-environment status as new research instruments. The same carcinogenesis process can be related also to endogenous agents that may have a major contribution in spontaneously process. (Reactive oxygen species (ROS), which are involved in multiple cellular processes by physiologically transporting signal as a second messenger or pathologically oxidizing DNA, lipids, and proteins).

Read Full Article HTML DOI: 10.29328/journal.acst.1001004 Cite this Article Read Full Article PDF

Keywords:

Endogenous toxicology; Physiology; Pharmacological strategies; New pathogenetic theories; Cancer; Metastasys

References

  1. Lakatos L, Pataki I, Balla G. Penicillamine - Neuroprotection against Neonatal Brain Injuries. Current Opinions in Neurological Science 2017; 1: 238-239. Ref.: https://goo.gl/RZ9UNu
  2. Luisetto M. Brain response in some systemic immune condition-Toxicological aspects. Insights Clin Cell Immunol. 2017; 1: 005-008. Ref.: https://goo.gl/jBPLMQ
  3. Luisetto M, Abadi BN, Mashori. Title Mindset Kinetics –Under Toxicological Aspect. Chronicles of Pharmaceutical Science. 2018; 1:: 369-371. https://goo.gl/FCdUht
  4. Maniscalco BS, Taylor KA. Calcifi cation in coronary artery disease can be reversed by EDT Atetracycline long-term chemotherapy. 2004; 11: 95-101. Ref.: https://goo.gl/GRwvzW
  5. Ross MK, Matthews AT, Mangum LC. Chemical Atherogenesis: Role of Endogenous and Exogenous Poisons in Disease Development. Toxics. 2014; 2: 17-34. Ref.: https://goo.gl/uH4SsF
  6. Paneni F, Beckman JA, Creager MA, Cosentino F. Published online 2013 May 2. Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I. Eur Heart J. 2013; 34: 2436–2443. Ref.: https://goo.gl/pXkRVP
  7. Luisetto M, Mashori GR, Nili-Ahmadabadi B, Khan FA, Khan KR. Mindset kinetics and some depression status: A new quantitative model under biochemical - toxicology approach? Insights Depress Anxiety. 2018; 2: 029-039. Ref.: https://goo.gl/3DBpZF
  8. Luisetto M, Naseer A, Ghulam RM, Ahmed YR, Farhan AK, et al. Endogenous Archeological Sciences: Anatomy, Physiology, Neuroscience, Biochemistry, Immunology, Pharmacology, Oncology, Genetics as Instrument for A New Field of Investigation? Modern Global Aspects for a New Discipline Open Access J Addict & Psychol. 1: 2018; 1-18. Ref.: https://goo.gl/466DfY
  9. Ma R, Feng Y, Lin S, Chen J, Lin H, et al. Mechanisms involved in breast cancer liver metastasis. J Transl Med. 2015; 13: 64. Ref.: https://goo.gl/wnpnHB
  10. Erler JT, Bennewith KL, Nicolau M, Dornhöfer N, Kong C, et al. Lysyl oxidase is essential for hypoxia-induced metastasis. Nature. 2006; 440: 1222-1226. Ref.: https://goo.gl/fEafBh
  11. Lutz WK, Fekete T. Endogenous and exogenous factors in carcinogenesis: limits to cancer prevention. Int Arch Occup Environ Health. 1996; 68: 120-125. Ref.: https://goo.gl/vMQYti
  12. Luisetto M. Intra- Local Toxicology Aspect Time Related in Some Pathologic Conditions. Open Acc J of Toxicol. 2017; 2: 002 555586. Ref.: https://goo.gl/JejVVq
  13. luisetto M, Ahmadabadi BN, Mashori GR. Heart disease new hypotesys: Under endogenous toxicological aspect. J Cardiol Cardiovasc Med. 2018; 3: 001-004. Ref.: https://goo.gl/e1awrc
  14. Swenberg JA, Lu K, Moeller BC, Gao L, Upton PB, et al. Endogenous versus Exogenous DNA Adducts: Their Role in Carcinogenesis, Epidemiology, and Risk Assessment. Toxicol Sci. 2011; 120 Suppl 1: S130-145. https://goo.gl/ZTK1fn
  15. Sim BK, MacDonald NJ, Gubish ER. Angiostatin and endostatin: endogenous inhibitors of tumor growth. Cancer Metastasis Rev. 2000; 19: 181-190. Ref.: https://goo.gl/X1eFmS
  16. Finch ER, Tukaramrao DB, Goodfield LL, Quickel MD, Paulson RF, et al. Activation of PPARγ by endogenous prostaglandin J2 mediates the antileukemic effect of selenium in murine leukemia. Blood 2017; 129: 1802-1810. Ref.: https://goo.gl/r7KigN
  17. Escobar-Khondiker M, Höllerhage M, Muriel MP, Champy P, Bach A, et al. Annonacin, a natural mitochondrial complex I inhibitor, causes tau pathology in cultured neurons. J Neurosci. 2007; 27: 7827-7837. Ref.: https://goo.gl/bbKDZG
  18. Xu J, Zhao M, Pei L, Zhang R, Liu X. et al. Oxidative stress and DNA damage in a long-term hexavalent chromium-exposed population in North China: a cross-sectional study. BMJ Open. 2018; 8: e021470. Ref.: https://goo.gl/m7Tiu4
  19. Luisetto M, Ahmadabadi BN, Ahmadabadi HN, Mashori GR, Hamid GA, et al. Similarity between Some Biological Systems, Organotropism and Metastatic Process: Active Role Played By Secondary Organ? Insights Biol Med. 2018; 2: 019-051. Ref.: https://goo.gl/1wcnDw
  20. Schwartz CJ, Kelley JL, Nerem RM, Sprague EA, Rozek MM, et al. Pathophysiology of the atherogenic process. Am J Cardiol. 1989; 64: 23G-30G. Ref.: https://goo.gl/tq2wxS
  21. Mogoantă SS, Vasile I, Totolici B, Neamţu C, Streba L, et al. Colorectal cancer - clinical and morphological aspects. Rom J Morphol Embryol. 2014; 55: 103-110. https://goo.gl/rAEyar
  22. Thakur MK, Ruterbusch JJ1, Schwartz AG1, Gadgeel SM1, Beebe-Dimmer JL, et al. Risk of Second Lung Cancer in Patients with Previously Treated Lung Cancer: Analysis of Surveillance, Epidemiology, and End Results (SEER) Data. J Thorac Oncol. 2018; 13: 46-53. Ref.: https://goo.gl/wN5qT4
  23. Luisetto M, Behzad N, Ghulam R M. Heart Disease New Hypotesys: Under Endogenous Toxicological Aspect. J Cardiol & Cardiovasc Ther 2018; 9: 555765. Ref.: https://goo.gl/7LDy3e
  24. Luisetto M, Nili-Ahmadabadi Bm, Mashori GR. Surgery and new Pharmacological strategy in some atherosclerotic chronic and acute conditions. Arch Surg Clin Res. 2017; 1: 042-048. Ref.: https://goo.gl/vCScb1
  25. West JD, Marnett LJ. Endogenous Reactive Intermediates as Modulators of Cell Signaling and Cell Death. Chem Res Toxicol. 2006; 19: 173-194. Ref.: https://goo.gl/osJu85
  26. Sim BK, MacDonald NJ, Gubish ER. Angiostatin and endostatin: endogenous inhibitors of tumor growth. Cancer Metastasis Rev. 2000; 19: 181-190. Ref.: https://goo.gl/6RBorZ
  27. Lutz WK, Fekete T. Endogenous and exogenous factors in carcinogenesis: limits to cancer prevention. Int Arch Occup Environ Health. 1996; 68: 120-125. Ref.: https://goo.gl/EuHCn5
  28. West JD, Marnett LJ. Endogenous Reactive Intermediates as Modulators of Cell Signaling and Cell Death. Chem Res Toxicol. 2006; 19: 173-194. Ref.: https://goo.gl/XZuJer
  29. Luisetto M, Ghulam RM, Behzad NA, Farhan AK, Kausar RK. Mindset kinetics and Some Depression Status: A New Quantitative Model Under Biochemical-Toxicology Approach? Insights Depress Anxiety. 2018; 2: 029-039. Ref.: https://goo.gl/U56v8X
  30. Patki G, Atrooz F, Alkadhi I, Solanki N, Salim S. High aggression in rats is associated with elevated stress, anxiety-like behavior, and altered catecholamine content in the brain. Neurosci Lett. 2015; 584: 308-313. Ref.: https://goo.gl/7U6c5x
  31. Wraith DC, Nicholson LB. The adaptive immune system in diseases of the central nervous. J Clin Invest. 2012; 122: 1172-1179. Ref.: https://goo.gl/BVCwpR
  32. Denison MS, Nagy SR. Activation of the Aryl Hydrocarbon Receptor by Structurally Diverse Exogenous and Endogenous Chemicals Annual Review of Pharmacology and Toxicology. Annu Rev Pharmacol Toxicol. 2003; 43: 309-334. Ref.: https://goo.gl/f3PKua
  33. Trosko JE, Madhukar BV, Chang CC. Endogenous and exogenous modulation of gap junctional intercellular communication: Toxicological and pharmacological implications. Life Sciences. 1993; 53: 1-19. Ref.: https://goo.gl/WdCVv2
  34. Deng B, Lv W, Duan W, Liu Y, Li Z, et al. Progressive Degeneration and Inhibition of Peripheral Nerve Regeneration in the SOD1-G93A Mouse Model of Amyotrophic Lateral Sclerosis. Cell Physiol Biochem. 2018; 46: 2358-2372. Ref.: https://goo.gl/eiLgXN
  35. Ross MK, Matthews AT, Mangum LC. Chemical Atherogenesis: Role of Endogenous and Exogenous Poisons in Disease Development. Toxics. 2014; 2: 17-34. Ref.: https://goo.gl/hPf6UQ
  36. Stancel GM, Boettger-Tong HL, Chiappetta C, Hyder SM, Kirkland JL, et al. Toxicity of endogenous and environmental estrogens: what is the role of elemental interactions? Environ Health Perspect. 1995; 103 Suppl 7: 29-33. Ref.: https://goo.gl/7igtmr
  37. Swenberg JA, Lu K, Moeller BC, Gao L, Upton PB, et al. Endogenous versus exogenous DNA adducts: their role in carcinogenesis, epidemiology, and risk assessment. Toxicol Sci. 2011; 120 Suppl 1: S130-145. Ref.: https://goo.gl/tSmDbY
  38. Marnett LJ, Plastaras JP. Endogenous DNA damage and mutation. Trends Genet. 2001; 17: 214-221. Ref.: https://goo.gl/D2vR5d
  39. Hussain SP, Harris CC. Molecular epidemiology and carcinogenesis: endogenous and exogenous carcinogens. Mutat Res. 2000; 462: 311-322. Ref.: https://goo.gl/h4KGVg

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