Abstract

Case Report

Cardiac metastases from merkel cell cancer: A case report and review of literature

Max Serge Duesberg and Deepti Behl*

Published: 05 July, 2022 | Volume 6 - Issue 1 | Pages: 004-005

A 61 - year-old physically fit and athletic man presented to his dermatologist with a 10 mm raised, dark lesion on the left side of his neck. A complete skin examination did not show any other abnormal areas of skin. Pathology was found consistent with Merkel cell cancer, and the patient was referred to surgery for a wide local excision and sentinel lymph node biopsy. A PET scan did not show any other areas of concern. At surgery, one of two sentinel lymph nodes was found to be involved with Merkel cell cancer and the patient received postoperative radiation.

Read Full Article HTML DOI: 10.29328/journal.acst.1001026 Cite this Article Read Full Article PDF

References

  1. Tothill R, Estall V, Rischin D. Emerging biology, current approaches, and future directioins. American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting. 2015.
  2. Santos-Juanes J, Fernández-Vega I, Fuentes N, Galache C, Coto-Segura P, Vivanco B, Astudillo A, Martínez-Camblor P. Merkel cell carcinoma and Merkel cell polyomavirus: a systematic review and meta-analysis. Br J Dermatol. 2015 Jul;173(1):42-9. doi: 10.1111/bjd.13870. Epub 2015 Jun 12. PMID: 25919492.
  3. Kassem A, Schöpflin A, Diaz C, Weyers W, Stickeler E, Werner M, Zur Hausen A. Frequent detection of Merkel cell polyomavirus in human Merkel cell carcinomas and identification of a unique deletion in the VP1 gene. Cancer Res. 2008 Jul 1;68(13):5009-13. doi: 10.1158/0008-5472.CAN-08-0949. PMID: 18593898.
  4. Paulson KG, Park SY, Vandeven NA, Lachance K, Thomas H, Chapuis AG, Harms KL, Thompson JA, Bhatia S, Stang A, Nghiem P. Merkel cell carcinoma: Current US incidence and projected increases based on changing demographics. J Am Acad Dermatol. 2018 Mar;78(3):457-463.e2. doi: 10.1016/j.jaad.2017.10.028. Epub 2017 Nov 2. PMID: 29102486; PMCID: PMC5815902.
  5. Garcia-Carbonero R, Marquez-Rodas I, de la Cruz-Merino L, Martinez-Trufero J, Cabrera MA, Piulats JM, Capdevila J, Grande E, Martin-Algarra S, Berrocal A. Recent Therapeutic Advances and Change in Treatment Paradigm of Patients with Merkel Cell Carcinoma. Oncologist. 2019 Oct;24(10):1375-1383. doi: 10.1634/theoncologist.2018-0718. Epub 2019 Apr 8. PMID: 30962295; PMCID: PMC6795164.
  6. Colunga A, Pulliam T, Nghiem P. Merkel Cell Carcinoma in the Age of Immunotherapy: Facts and Hopes. Clin Cancer Res. 2018 May 1;24(9):2035-2043. doi: 10.1158/1078-0432.CCR-17-0439. Epub 2017 Dec 7. PMID: 29217527; PMCID: PMC5932211.
  7. Bussani R, De-Giorgio F, Abbate A, Silvestri F. Cardiac metastases. J Clin Pathol. 2007 Jan;60(1):27-34. doi: 10.1136/jcp.2005.035105. Epub 2006 Nov 10. PMID: 17098886; PMCID: PMC1860601.
  8. Chiles C, Woodard PK, Gutierrez FR, Link KM. Metastatic involvement of the heart and pericardium: CT and MR imaging. Radiographics. 2001 Mar-Apr;21(2):439-49. doi: 10.1148/radiographics.21.2.g01mr15439. PMID: 11259706.
  9. Suttie CF, Hruby G, Horvath L, Thompson J. Cardiac metastasis in Merkel cell carcinoma. J Clin Oncol. 2014 May 1;32(13):e52-3. doi: 10.1200/JCO.2012.48.3073. Epub 2014 Jan 27. PMID: 24470001.

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